L-Arginine and L-Citrulline are amino acids involved in the cyclic process of synthesizing nitric oxide (NO)—a molecule naturally produced by the body that is crucial for maintaining the integrity of the vascular endothelium (the tissue lining the inner surface of blood vessels). Nitric oxide plays a key role in vasodilation and the inhibition of platelet aggregation. Willow dry extract, thanks to its salicin content, helps alleviate localized tension. Furthermore, once ingested, salicin is metabolized into salicylic acid, a substance known for its anti-platelet aggregation properties.
Magnesium is a mineral with muscle-relaxing properties; it contributes to normal muscle function, energy-yielding metabolism, and electrolyte balance. Probenat GZ features the innovative patented MAGSHAPE microcapsules—a form of micronized, microencapsulated magnesium that offers superior intestinal absorption and higher bioavailability compared to other forms of magnesium.
Folate contributes to maternal tissue growth during pregnancy. Supplemental folic acid intake increases maternal folate status. Low maternal folate status is a risk factor for the development of neural tube defects in the fetus (the beneficial effect is achieved with a daily supplemental intake of 400 μg of folic acid for at least one month before and up to three months after conception). QUATREFOLIC (the glucosamine salt of (6S)-5-methyltetrahydrofolate), found in Probenat GZ, represents the active form of folic acid, making it immediately available to the body's cells without requiring prior metabolism. Folate supplementation in the form of QUATREFOLIC is also indicated for individuals with genetic mutations that hinder the proper conversion of folic acid into its active form (e.g., MTHFR gene mutation). Iodine: an essential mineral for the proper functioning and health of the thyroid gland.
Vitamins C & D: vitamins that help prevent placental oxidative stress. Vitamin B12: a water-soluble vitamin that contributes to normal energy metabolism.
References:
1. Camareda Pulido E.E. et al., Hypertens Pregnancy. 2016; 35(2):217-225.
2. Weckman A.M. et al., Adv Nutr. 2019; 10(5):765-777.